On the evening of September 23, 2024, the NFL will see the Jacksonville Jaguars square off against the Buffalo Bills at Highmark Stadium in Orchard Park, with the kickoff scheduled for 7:30 PM. The Jaguars currently stand third in their division and fifteenth in the conference, facing an uphill battle with a season start of 0-2-0, which equates to a 0.00 winning percentage. They have accumulated 30 points while conceding 38, resulting in a negative net point difference of -8. In stark contrast, the Bills have enjoyed a strong opening, topping both their division and conference with a flawless 2-0-0 record and a 1.00 winning percentage. Their offense has chalked up 65 points against a defense allowing 38, giving them a positive net difference of 27. In their most recent match-ups, the Jaguars were bested by Cleveland with a tight score of 13 to 18 at EverBank Stadium, achieving 18 first downs and amassing 127 rushing yards along with 196 passing yards. Meanwhile, the Bills triumphed over Miami with a commanding 31 to 10 at Hard Rock Stadium, gathering 13 first downs, 108 rushing yards, and 139 passing yards. Key player performances saw Jacksonville’s Trevor Lawrence throwing for 220 yards with a passer rating of 71.53, though without touchdowns, while Buffalo’s Josh Allen marked 139 passing yards, scoring a touchdown with a commendable passer rating of 107.13. The match promises an engrossing contest between these two quarterbacks and their teams. For bettors, the odds are particularly intriguing. The Bills are favored with a point spread of -3.50, reflecting their strong start to the season, while the Jaguars are positioned at +3.50. The game’s total score is pegged at an over/under of 47.50. Direct moneyline bets are also active, with the Bills at -185 indicating a higher probability of winning, compared to the Jaguars at +154. These numbers suggest anticipation of a high-scoring game with strong defensive plays, potentially rewarding strategic bets. For updates on this and other fixtures, keep an eye on betNewYorksports.com.