On November 2, 2025, an exciting NFL matchup is set to take place as the Kansas City Chiefs go head to head with the Buffalo Bills at Highmark Stadium in Orchard Park. The kickoff is scheduled for 4:25 PM.

Last season, the Kansas City Chiefs finished second in their division and seventh in their conference, holding a record of 2-2-0, which translates to a .500 winning percentage. They totaled 97 points for and 76 points against, resulting in a point differential of +21.

The Buffalo Bills, showcasing a dominant start, topped their division and conference with an impeccable 4-0-0 record and a 1.00 winning percentage. They amassed 133 points while conceding 90, boasting a net differential of +43.

In their latest outings, the Chiefs overcame the San Francisco 49ers 28-18 at Levi’s Stadium, accumulating 22 first downs along with 184 rushing yards and 145 passing yards. Conversely, the Bills routed the Tennessee Titans 34-10, securing 18 first downs, 74 rushing yards, and an impressive 315 passing yards.

A key highlight is the quarterback duel between Patrick Mahomes of the Chiefs, who last week threw for 154 yards and a rating of 44.37, and Josh Allen of the Bills, who passed for 323 yards and 2 touchdowns, earning a rating of 116.1.

As we look towards the odds for the upcoming game at betNewYorksports.com, the Buffalo Bills are currently favored at home with a point spread of -2.50 against the Kansas City Chiefs who stand at +2.50. The over/under for this matchup is set at 48.70, indicating expectations of a high-scoring game. For those preferring straight results, the moneyline odds are -143 for the Bills and +121 for the Chiefs. This setup suggests a tightly contested battle, with the outcome likely swinging on pivotal plays and critical quarterback performances.